Use of Oral Hypoglycemic Agent in Pregnancy: How far have We Reached?

The HAPO Study Cooperative Research Group stated that the adverse perinatal outcomes were proportional to hyperglycemia in pregnancy [2]. Hyperglycemia results in complications like fetal hyperinsulinemia, birth trauma and macrosomia. These effects were translated into the adult life which increases the risk of obesity, metabolic syndromes and Type 2 diabetes [3]. Euglycemia ensures favourable outcome in diabetic pregnancies as promoted by the American College of Obstetricians and Gynaecologists and American Diabetes Association thereby assuring maternal well-being and reduction in adverse perinatal outcomes [4,5].